RENOSEV Tablet

440.00৳ 

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Medicine Overview of Renosev 800mg tablet

Introduction

Renosev 800 is used to treat increased phosphate level in the blood. It is used in patients who are on dialysis due to severe kidney disease. It inhibits the absorption of phosphate from the intestine and lower the phosphate levels in the blood.

Renosev 800 should be taken with food. Take it in the dose and duration as advised by your doctor. Take it regularly and at a fixed time each day to get maximum benefit of the medicine.

Using of Renosev 800 may cause side effects such as nausea, vomiting, abdominal pain, constipation and diarrhea. You may also develop low levels of calcium, folic acid and vitamins A, D, E and K in your blood. Take necessary supplements as advised by your doctor.

 

Uses of Renosev 800
  • High phosphate levels in blood
Side effects of Renosev 800
Common
  • Nausea
  • Vomiting
  • Upper abdominal pain
  • Flatulence
  • Constipation
  • Diarrhea
How to use Renosev 800
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Renosev 800 is to be taken with food.
How Renosev 800 works
Renosev 800 inhibits the absorption of phosphate from the intestine and lower the phosphate levels in the blood.
What if you forget to take Renosev 800?
If you miss a dose of Renosev 800, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
  • Renosev 800 is used to control blood phosphate level in patients that are on dialysis treatment.
  • You must take it with food and stick to the diet prescribed by your doctor.
  • You may develop low levels of calcium, folic acid, and vitamins A,D,E, and K in your blood. Your doctor may prescribe supplements, if necessary.

     

  • Avoid taking any other medicine 1 hour before or 3 hours after taking Renosev 800.
  • Inform your doctor if you have nausea, vomiting, constipation, pain in the abdomen, or if you have undergone any major stomach surgery.
Brief Description
Indication
Hyperphosphataemia
Administration
Should be taken with food.
Adult Dose
End-Stage Renal Disease
Hemodialysis; hyperphosphatemiaInitial dose
Serum PO4 >9 mg/dL [2.91 mmol/L]: 1600 mg PO q8hr with meals
Serum PO4 7.5-9 mg/dL [2.42-2.91 mmol/L]: 1200-1600 mg PO q8hr with meals
Serum PO4 5.5-7.5 mg/dL [1.78-2.42 mmol/L]: 800 mg PO q8hr with meals

Maintenance dose
Serum PO4 >5.5 mg/dL [>1.78 mmol/L]: Increase dose by 400-800 mg per meal
Serum PO4 3.5-5.5 mg/dL [1.13-1.78 mmol/L]: Maintain current dose
Serum PO4 <3.5 mg/dL [1.13 mmol/L] decrease by 400-800 mg per meal

Dosing considerations
Titrate dose; increase by 400-800 mg per meal at 2-week intervals; no more than 4 g

Switching From Ca-Acetate
Substitute 800 mg for 667 mg of Ca-acetate
Substitute 1600 for1334 mg of Ca-acetate
Substitute 2400 mg for 2001 mg Ca-acetate

 

Child Dose
Safety and efficacy not established
Contraindication
Hypophosphatemia or bowel obstruction.
Mode of Action
Sevelamer, a polymeric compound, acts by binding to phosphate molecules in the gut, limiting its absorption and thus lowering serum phosphate levels w/o altering Ca, Al, or bicarbonate levels.

 

Precaution

Patients w/ dysphagia, swallowing disorders, severe GI motility disorders, active inflammatory bowel disease or major GI tract surgery. Pregnancy and lactation. Monitoring Parameters Monitor serum levels of phosphate, Ca, Cl and bicarbonate. Vitamin supplementation due to reduction in vit D, E, K and folic acid absorption. Monitor for signs and symptoms of peritonitis in patients undergoing peritoneal dialysis.

Lactation: Not absorbed systemically; not excreted in breast milk

 

Side Effect
>10%
Vomiting (22%),Nausea (20%),Diarrhea (19%),Dyspepsia (16%),Nasopharyngitis (14%),Limb pain (13%),Pruritus (13%),Arthralgia (12%),Bronchitis (11%),Dyspnea (10%),Hypertension (10%)1-10%
Abdominal pain (9%),Constipation (8%),Flatulence (8%),Peritonitis (during peritoneal dialysis: 8%),Hypercalcemia (5-7%)

Frequency Not Defined
Back pain,Cough,Headache,Pyrexia,Upper respiratory infection,Pruritus,Rash,Intestinal perforation,Fecal impaction,Intestinal obstruction.

 

Interaction
May decrease absorption of ciprofloxacin, ciclosporin, mycophenolate, tacrolimus and levothyroxine. Sevelamer should be given 3 hr before or 1 hr after taking other drugs to minimise potential pharmacokinetic interaction.

 

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RENOSEV Tablet

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