CORABID 5mg Tablet

490.00৳ 

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Medicine Overview of Corabid 7.5mg Tablet

Introduction

Corabid is a medicine used for treatment of angina (heart-related chest pain) and chronic (long-term) heart failure. It makes the heart work more efficiently by lowering the heart rate. This relieves chest pain and decreases the risk of hospitalization in heart failure patients.

The dose will depend on what you are being treated for. Since the treatment for angina or heart failure is usually life-long, you should not stop using it without talking to your doctor. It should be taken with food at the same time each day. If you take too much in one go, your heart could slow down too much and make you feel breathless or tired. If this happens, call a doctor.

The most common side effects are temporary brightness in your vision and changes to your heart function. You may also experience uncontrolled blood pressure, headache, dizziness and blurred vision. Some side effects such as fainting and significant changes to your heartbeat may be very serious and may need urgent medical attention. Avoid driving until you know how this medicine will affect you.

Do not use Corabid if you have severe liver disease, have a low resting heart rate or a heart rhythm disorder. This medicine is also not suitable if you have very low blood pressure and heart failure that has recently become worse. This medicine interacts with certain other medicines used to treat high blood pressure, fungal infections and HIV. Do not take it if you are pregnant, trying to become pregnant, or breastfeeding.

 

Uses of Corabid
  • Angina (heart-related chest pain)
  • Heart failure
Side effects of Corabid
Common
  • Slow heart rate
  • Headache
  • Luminous phenomena (Enhanced brightness)
  • High blood pressure
How to use Corabid
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Corabid is to be taken with food.
How Corabid works
Corabid is a heart rate lowering medication. It works by reducing the heart rate which lowers the oxygen requirement of the heart. As a result, the heart works more efficiently.
What if you forget to take Corabid?
If you miss a dose of Corabid, skip it and continue with your normal schedule. Do not double the dose.
Quick Tips
  • Corabid may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
  • You may experience temporary changes in your vision such as enhanced visual brightness. These changes may occur within the initial 2 months of treatment and should gradually go away.

     

  • Monitor your blood pressure when taking Corabid as it can increase your blood pressure.
  • Monitor your heart rate when taking this medicine, as low heart rate is a common side effect. Inform your doctor if you experience symptoms of low heart rate such as dizziness, tiredness and low energy.

     

Brief Description
Indication
Chronic stable angina, Heart Failure
Administration
Should be taken with food. Avoid excessive consumption of grapefruit juice.
Adult Dose
Oral
Heart Failure
Initial: 5 mg PO BID with meals (all see Dosage Modifications)After 2 weeks, assess patient and adjust dose to achieve a resting heart rate of 50-60 bpm (see dose adjustment section below)
Thereafter, adjust dose prn based on resting heart rate and tolerability; not to exceed 7.5 mg BIDDose adjustment
HR >60 bpm: Increase dose by 2.5 mg (given twice daily) up to a maximum dose of 7.5 mg BID
HR 50-60 bpm: Maintain dose
HR <50 bpm or signs and symptoms of bradycardia: Decrease dose by 2.5 mg (given twice daily); if current dose is 2.5 mg BID, discontinue therapy

Chronic stable angina pectoris in coronary artery disease patients with normal sinus rhythm
Adult: Initially, should not exceed 5 mg bid. Increase if necessary to 7.5 mg bid after 3-4 wk.
Titrate downward to as low as 2.5 mg bid, if patient develops bradycardia symptoms (e.g. dizziness, fatigue) or resting heart rate is persistently <50 beats/min.

Elderly: >75 yr Initiate treatment at 2.5 mg bid. Titrate up if necessary.

Hepatic impairment
Mild or moderate (Child-Pugh A or B): No dose adjustment required
Severe (Child-Pugh C): Contraindicated

 

Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment:
CrCl (ml/min)tDosage Recommendation
<15tUse w/ caution.
Contraindication
Pregnancy, lactation, resting heart rate <60 beats/min prior to treatment, cardiogenic shock, acute myocardial infarction, severe hypotension (<90/50 mmHg), severe hepatic insufficiency, sick sinus syndrome, sino-atrial block, heart failure patients with NYHA class III-IV, pacemaker dependent, unstable angina, 3rd degree AV-block, concurrent use with potent CYP3A4 inhibitors.

 

Mode of Action
Ivabradine is a heart rate lowering agent that works through selective and specific inhibition of the cardiac pacemaker If current. If current controls the spontaneous diastolic depolarisation in the sinus node and regulate heart rate.

 

Precaution
Reduce dose if resting heart rate is persistently <50 beats/min or patient develops bradycardia symptoms during treatment; discontinue if heart rate <50 beats/min and symptoms persist. Not recommended in patient with AF or other cardiac arrhythmias that interfere with sinus node rhythm; monitor regularly for AF occurrence. Not recommended for concomitant use with heart rate reducing calcium channel blockers (e.g. diltiazem or verapamil), immediate use after a stroke or in patients with 2nd degree AV-block. Severe renal insufficiency, Moderate hepatic insufficiency. Stop treatment if visual field deteriorates unexpectedly. Patients with retinitis pigmentosa.

 

Side Effect
1-10%
Bradycardia (10%)
Hypertension or increased blood pressure (8.9%)
Atrial fibrillation (8.3%)
Luminous phenomena (phosphenes) or visual brightness (2.8%)

 

Interaction

Concomitant use with QT-prolonging drugs (e.g. quinidine, disopyramide, bepridil, sotalol, ibutilide, amiodarone, pimozide, ziprasidone, sertinole, mefloquine, halofantrine, pentamide, cisapride, erythromycin IV) is not recommended as QT prolongation may be enhanced by heart rate reduction. Concentrations may increase when used with CYP3A4 inhibitors. Use with verapamil or diltiazem (moderate CYP3A4 inhibitors) is not recommended. If used with other moderate CYP3A4 inhibitors (e.g. fluconazole), may consider starting at lower dose and with heart rate monitoring if resting heart rate >60 beats/min. Concentration may be reduced with CYP3A4 inducers (e.g. rifampicin, barbiturates, phenytoin, St John’s Wort) and may require Ivabradine dose adjustment.

Potentially Fatal: Concurrent use with potent CYP3A4 inhibitors is contraindicated; e.g. azole antifungals (ketoconazole, itraconazole), macrolides (clarithromycin, erythromycin PO, josamycin, telithromycin), HIV protease inhibitors (nelfinavir, ritonavir) and nefazodone.

 

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CORABID 5mg Tablet

490.00৳ 

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    490.00৳ 

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