CORABID 5mg Tablet
490.00৳
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Size Guide
DRESSEST-SHIRTBOTTOMSDRESSESSize Chest Waist Hips XS 34 28 34 S 36 30 36 M 38 32 38 L 40 34 40 XL 42 36 42 2XL 44 38 44 All measurements are in INCHES
and may vary a half inch in either direction.
T-SHIRTSize Chest Waist Hips 2XS 32 26 32 XS 34 28 34 S 36 30 36 M 38 32 38 L 40 34 40 XL 42 36 42 All measurements are in INCHES
and may vary a half inch in either direction.
BOTTOMSSize Chest Waist Hips XS 34 28 34 S 36 30 36 M 38 32 38 L 40 34 40 XL 42 36 42 2XL 44 38 44 All measurements are in INCHES
and may vary a half inch in either direction.
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Medicine Overview of Corabid 7.5mg Tablet
Corabid is a medicine used for treatment of angina (heart-related chest pain) and chronic (long-term) heart failure. It makes the heart work more efficiently by lowering the heart rate. This relieves chest pain and decreases the risk of hospitalization in heart failure patients.
The dose will depend on what you are being treated for. Since the treatment for angina or heart failure is usually life-long, you should not stop using it without talking to your doctor. It should be taken with food at the same time each day. If you take too much in one go, your heart could slow down too much and make you feel breathless or tired. If this happens, call a doctor.
The most common side effects are temporary brightness in your vision and changes to your heart function. You may also experience uncontrolled blood pressure, headache, dizziness and blurred vision. Some side effects such as fainting and significant changes to your heartbeat may be very serious and may need urgent medical attention. Avoid driving until you know how this medicine will affect you.
Do not use Corabid if you have severe liver disease, have a low resting heart rate or a heart rhythm disorder. This medicine is also not suitable if you have very low blood pressure and heart failure that has recently become worse. This medicine interacts with certain other medicines used to treat high blood pressure, fungal infections and HIV. Do not take it if you are pregnant, trying to become pregnant, or breastfeeding.
- Angina (heart-related chest pain)
- Heart failure
- Slow heart rate
- Headache
- Luminous phenomena (Enhanced brightness)
- High blood pressure
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Corabid may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.
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You may experience temporary changes in your vision such as enhanced visual brightness. These changes may occur within the initial 2 months of treatment and should gradually go away.
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Monitor your blood pressure when taking Corabid as it can increase your blood pressure.
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Monitor your heart rate when taking this medicine, as low heart rate is a common side effect. Inform your doctor if you experience symptoms of low heart rate such as dizziness, tiredness and low energy.
Heart Failure
Initial: 5 mg PO BID with meals (all see Dosage Modifications)After 2 weeks, assess patient and adjust dose to achieve a resting heart rate of 50-60 bpm (see dose adjustment section below)
Thereafter, adjust dose prn based on resting heart rate and tolerability; not to exceed 7.5 mg BIDDose adjustment
HR >60 bpm: Increase dose by 2.5 mg (given twice daily) up to a maximum dose of 7.5 mg BID
HR 50-60 bpm: Maintain dose
HR <50 bpm or signs and symptoms of bradycardia: Decrease dose by 2.5 mg (given twice daily); if current dose is 2.5 mg BID, discontinue therapy
Chronic stable angina pectoris in coronary artery disease patients with normal sinus rhythm
Adult: Initially, should not exceed 5 mg bid. Increase if necessary to 7.5 mg bid after 3-4 wk.
Titrate downward to as low as 2.5 mg bid, if patient develops bradycardia symptoms (e.g. dizziness, fatigue) or resting heart rate is persistently <50 beats/min.
Elderly: >75 yr Initiate treatment at 2.5 mg bid. Titrate up if necessary.
Hepatic impairment
Mild or moderate (Child-Pugh A or B): No dose adjustment required
Severe (Child-Pugh C): Contraindicated
CrCl (ml/min)tDosage Recommendation
<15tUse w/ caution.
Bradycardia (10%)
Hypertension or increased blood pressure (8.9%)
Atrial fibrillation (8.3%)
Luminous phenomena (phosphenes) or visual brightness (2.8%)
Concomitant use with QT-prolonging drugs (e.g. quinidine, disopyramide, bepridil, sotalol, ibutilide, amiodarone, pimozide, ziprasidone, sertinole, mefloquine, halofantrine, pentamide, cisapride, erythromycin IV) is not recommended as QT prolongation may be enhanced by heart rate reduction. Concentrations may increase when used with CYP3A4 inhibitors. Use with verapamil or diltiazem (moderate CYP3A4 inhibitors) is not recommended. If used with other moderate CYP3A4 inhibitors (e.g. fluconazole), may consider starting at lower dose and with heart rate monitoring if resting heart rate >60 beats/min. Concentration may be reduced with CYP3A4 inducers (e.g. rifampicin, barbiturates, phenytoin, St John’s Wort) and may require Ivabradine dose adjustment.
Potentially Fatal: Concurrent use with potent CYP3A4 inhibitors is contraindicated; e.g. azole antifungals (ketoconazole, itraconazole), macrolides (clarithromycin, erythromycin PO, josamycin, telithromycin), HIV protease inhibitors (nelfinavir, ritonavir) and nefazodone.
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