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UCARDOL-6.25 Tablet

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Medicine Overview of Ucardol 6.25 6.25mg Tablet

Introduction

Ucardol 6.25 is a medicine used to treat high blood pressure, heart related chest pain (angina) and heart failure. It works by relaxing the blood vessels, so blood can flow more easily to the heart. Lowering blood pressure helps to prevent future heart attack and stroke.

Ucardol 6.25 should be taken with food. You should take it in the dose and duration as advised by the doctor. It is important to take it even if you feel well or if your blood pressure is controlled. You should not stop this medicine without talking to the doctor as your condition could get worse. Thus, your doctor will decide the time period till which you need to take this medicine.

Making some changes in your lifestyle will help in improving your condition. These may include regular exercise, losing weight, smoking cessation, reducing alcohol intake, and reducing the amount of salt in your diet as advised by your doctor. This medicine is tolerated well by most patients but it has few side effects also. Some patients may experience dizziness, so you should avoid driving after taking the medicine. Other side effects include headache and tiredness. Let your doctor know if these side effects bother you or do not go away. You should keep monitoring your blood pressure as this medicine may reduce it.

Before taking this medicine, let your doctor know if you have any heart or kidney disease. Pregnant or breastfeeding mothers should also consult their doctor before taking it.

Uses of Ucardol 6.25

Hypertension (high blood pressure)
Angina (heart-related chest pain)
Heart failure

Side effects of Ucardol 6.25

Common

Decreased blood pressure
Headache
Fatigue
Dizziness

How to use Ucardol 6.25

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ucardol 6.25 is to be taken with food.

How Ucardol 6.25 works

Ucardol 6.25 is an alpha and beta blocker. It works by slowing down the heart rate and relaxing blood vessels which makes the heart more efficient at pumping blood around the body.

Quick Tips

It should be taken with food.

Check your blood pressure 1 week after starting Ucardol 6.25, and inform your doctor if it has not improved.

Ucardol 6.25 may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you.

It is best to avoid drinking alcohol while taking Ucardol 6.25 as it may make the side effects worse.

Do not stop taking Ucardol 6.25 suddenly as it can cause your blood pressure to rise suddenly, thereby increasing the risk of heart attack and stroke.

Brief Description

Indication

Hypertension, Congestive heart failure, Myocardial infarction, Left ventricular dysfunction, Angina pectoris

Administration

Should be taken with food.

Adult Dose

Congestive Heart Failure
Immediate release
3.125 mg PO q12hr for 2 weeks, then increased every 2 weeks as tolerated to 6.25 mg, 12.5 mg, or 25 mg PO twice daily
Maximum recommended dosage (mild-to-moderate heart failure): <85 kg, 25 mg PO q12hr; >85 kg: 50 mg PO twice daily
Maximum recommended dosage (severe heart failure): 25 mg PO twice dailyExtended release
10 mg/day PO; maintained for 1-2 weeks if tolerated; may be increased to 20 mg/day, 40 mg/day, or 80 mg/day PO if necessary

Hypertension
Immediate release: 6.25 mg PO twice daily initially; after 7-14 days, increased as tolerated, first to 12.5 mg PO twice daily and then to 25 mg PO twice daily

Extended release: 20 mg/day PO; maintained for 1-2 weeks if tolerated; may be increased to 40 mg/day PO if necessary; not to exceed 80 mg/day PO

Left Ventricular Dysfunction Following Myocardial Infarction
Immediate release: 3.125-6.25 mg PO q12hr initially; after 3-10 days, increased as tolerated, first to 12.5 mg PO q12hr and then to 25 mg PO q12hr (target dosage)

Extended release: 10-20 mg/day PO; increased every 3-10 days as tolerated up to 80 mg/day PO (target dosage)

Angina pectoris
25-50 mg PO twice daily

Hepatic impairment: Contraindicated in severe liver impairment

Child Dose

Safety and efficacy not established

Renal Dose

Renal impairment: No dosage adjustments necessary

Contraindication

Hypersensitivity; severe chronic heart failure, bronchial asthma or related bronchospastic conditions; severe hepatic impairment. Patients with NYHA class IV cardiac failure, 2nd or 3rd ° AV block, sick sinus syndrome (unless a permanent pacemaker is in place), cardiogenic shock or severe bradycardia. Lactation.

Mode of Action

Carvedilol is a nonselective beta-adrenoreceptor and alpha-adrenergic blocking activity. It exerts antihypertensive effect partly by reducing total peripheral resistance and vasodilation.

Precaution

Avoid abrupt withdrawal as it may precipitate thyroid storm or exacerbate hyperthyroidism. Liver injury; vascular disease, renal failures, suspected phaeochromocytoma and prinzmetal’s variable angina; worsening cardiac failure or fluid retention during increase in dosage of carvedilol; diabetic patients. Pregnancy.

Lactation: Unknown whether drug is excreted in milk; not recommended

Side Effect

>10%
Dizziness (2-32%),Fatigue (4-24%),Hypotension (9-20%),Weight gain (10-12%),Hyperglycemia (5-12%),Diarrhea (1-12%)1-10%
Bradycardia (2-10%),Nausea (2-9%),Cough (5-8%),Headache (5-8%),Atrioventricular block, edema (1-7%),Angina (1-6%),Hpercholesterolemia (1-4%),Hypertriglyceredemia (1%),Vomiting (1-6%),Dyspnea (>3%),Syncope (3%),Rhinitis (2%)

Frequency Not Defined
Hypertension,Palpitations,Insomnia,Somnolence,Skin rash,Hepatotoxicity,Impotence,Bronchospasm,Rales,Depression,Decreased exercise tolerance,Raynaud phenomenon,Increased triglyceride levels and insulin resistance with decreased high-density lipoprotein (HDL) levels

Pregnancy Category Note

Pregnancy
Available data in pregnant women are insufficient to determine whether there are drug-associated risks of adverse developmental outcomes; there are risks to mother and fetus associated with poorly controlled hypertension in pregnancy; the use of beta blockers during third trimester of pregnancy may increase risk of hypotension, bradycardia, hypoglycemia, and respiratory depression in neonates; in animal reproduction studies, there was no evidence of adverse developmental outcomes at clinically relevant doses; observe newborns for symptoms of hypotension, bradycardia, hypoglycemia, and respiratory depression and manage accordinglyHypertension in pregnancy increases maternal risk for pre-eclampsia, gestational diabetes, premature delivery, and delivery complications (e.g., need for cesarean section and post-partum hemorrhage); hypertension increases fetal risk for intrauterine growth restriction and intrauterine death; pregnant women with hypertension should be carefully monitored and managed accordingly

Lactation
There are no data on presence of carvedilol in human milk, effects on breastfed infant, or on milk production; drug is present in the milk of lactating rats; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed infant from treatment or from underlying maternal condition

Interaction

Decreased serum levels w/ rifampicin. Combination w/ Ca channel blockers (e.g. verapamil and diltiazem) can lead to bradycardia and myocardial depress…

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Categories: Cardiovascular System, Medicine

Size	Chest	Waist	Hips
XS	34	28	34
S	36	30	36
M	38	32	38
L	40	34	40
XL	42	36	42
2XL	44	38	44
All measurements are in INCHES and may vary a half inch in either direction.

Size	Chest	Waist	Hips
2XS	32	26	32
XS	34	28	34
S	36	30	36
M	38	32	38
L	40	34	40
XL	42	36	42
All measurements are in INCHES and may vary a half inch in either direction.

Size	Chest	Waist	Hips
XS	34	28	34
S	36	30	36
M	38	32	38
L	40	34	40
XL	42	36	42
2XL	44	38	44
All measurements are in INCHES and may vary a half inch in either direction.

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UCARDOL-6.25 Tablet

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Medicine Overview of Ucardol 6.25 6.25mg Tablet

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UCARDOL-6.25 Tablet

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