SYLHEP 140mg Capsule

330.00৳

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Description

Medicine Overview of Sylhep 140mg Capsule

Introduction

Sylhep is a flavonoid derived from Silybum marianum, a plant commonly known as milk thistle. Sylhep exhibits hepatoprotective and regenerative properties and is one of the most widely used natural compounds for the treatment of hepatic diseases worldwide, due to its antioxidant, anti-inflammatory, and antifibrotic activities. Sylhep also increases hepatic levels of glutathione by raising cysteine availability, while inhibiting its catabolism to taurine that may enhance the antioxidant defense in liver. Sylhep was found to oppose oxidative stress, and to slow the progression of hepatic fibrosis in alcohol-fed baboons.

Uses of Sylhep

Sylhep is used for the treatment of Jaundice,chronic inflammatory liver conditions, hepatic cirrhosis ,alcoholic liver damage.

Side effects of Sylhep

Sometimes it cause

Mild digestive upset
Allergic reactions

How to use Sylhep

Take Sylhep in the dose and duration as advised by your doctor. Take Sylhep orally with plenty of water. Do not chew, crush or break it.

How Sylhep work

Different mechanisms of action of Sylhep are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as Sylhep has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of Sylhep is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp), organic anion uptake transporter peptides (OATP), bile salt export pump, and TNF-α-dependent transporters.

What if you forget to take Sylhep

If you forget to take yourSylhep , take them as soon as you remember. If it is almost time for your next dose, skip the missed dose and take it at the usual time. Avoid taking two doses at the same time.

Brief Description

Indication

It is used for the treatment and prevention of-
Liver disease, (non-alcoholic & alcoholic) ,
Liver cirrhosis, (non-alcoholic & alcoholic)
Infectious hepatitis,
Drug-induced hepatitis,
Liver disease secondary to diabetes mellitus,
Toxicity of narcotics,
Fatty liver,
Jaundice.

Administration

Administered only orally as advised by the physician.

Adult Dose

1 to 3 capsule(s) should be taken into 2 to 3 times daily or medication should be continued until the relief of symptoms according to the advice of physician.

Child Dose

It should not be given to children without advice of physician. Uses for below 12 years recommended after discussion
with registered physician.

Renal Dose

It should be used with caution in patients with kidney disease. Dose adjustment of Silymarin [Milk thistle] may be needed. Please consult your doctor.

Contraindication

Contraindicated in patient with a known hypersensitivity to silymarin.

Mode of Action

Different mechanisms of action of silymarin are as follow: Increasing the regenerative ability of the liver cells by enhancing the synthesis of DNA and RNA, as silymarin has a steroid structure; Altering the structure of the hepatocyte external membrane, that prevents entrance of the xenobiotics into the cell (poisoning with Amanita mushroom is a noteworthy example of such mechanism); Scavenging free radicals and increasing the cellular content of glutathione that leads to the inhibition of lipid peroxidation; Another mechanism of action of silymarin is modifying the transporters and receptors of cell membranes such as ABC transporters (P-gp), organic anion uptake transporter peptides (OATP), bile salt export pump, and TNF-α-dependent transporters.

Precaution

Over doses may mildly elevate blood pressure. Safety in young children or individuals with severe hepatic or renal disease is not known.

Side Effect

Occasionally a mild laxative effect may observe. Well tolerated in the recommended dose.

Pregnancy & Lactation Category Note

Therefore, if needed Silymarin should be taken with caution according to the physician’s advice. No established evidence is available about the use of Silymarin during pregnancy and lactation.

Interaction

Concomitant use of silymarin and butyrophenones or phenothiazines has resulted in the reduction of lipid peroxidation.

Storage Condition

Store in a cool & dry place, away from light & moisture. Keep out of reach of children.

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Category: Harbal