Palimax ER Tablet 6 mg (1 Strip=10 Pieces)
Original price was: 160.00৳ .152.00৳ Current price is: 152.00৳ .
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Indications
Palimax ER extended release tablet is indicated for-
- Schizophrenia, including acute treatment and recurrence prevention
- Treatment of schizoaffective disorder as monotherapy and in combination with antidepressants or mood stabilizers
* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন‘
Pharmacology
Paliperidone is a psychotropic agent belonging to the chemical class of benzisoxazole derivatives. Paliperidone is the major active metabolite of Risperidone. It is a centrally active dopamine Type 2 (D2) antagonist and with predominant serotonin Type 2 (5-HT2A) antagonist activity. It is also active as an antagonist at α1 and α2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. It has no affinity for cholinergic muscarinic or β1-and β2-adrenergic receptors.
Dosage
Schizophrenia:
- Adults: Initial dose is 6 mg/day. Recommended dose is 3-12 mg/day, Maximum dose is 12 mg/day
- Adolescents (Weight <51kg): Initial dose is 3 mg/day, Recommended dose is 3-6 mg/day, Maximum dose is 6 mg/day
- Adolescents (Weight ≥51kg): Initial dose is 3 mg/day, Recommended dose is 3-12 mg/day, Maximum dose is 12 mg/day
Schizoaffective disorder: adults Initial dose is 6 mg/day. Recommended dose is 3-12 mg/day, Maximum dose is 12 mg/day.
* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন‘
Administration
Paliperidone extended release tablet can be taken with or without food. It must be swallowed whole with the aid of liquids. Tablets should not be chewed, divided or crushed.
* রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন‘
Interaction
- Palimax ER should be used with caution in combination with other centrally acting drugs and alcohol. It may antagonize the effect of Levodopa and other dopamine agonists.
- Because of its potential for inducing orthostatic hypotension, an additive effect may be observed when Palimax ER is administered with other therapeutic agents that have this potential.
- Strong CYP3A4/P-glycoprotein (P-gp) inducers: It may be necessary to increase the dose of Palimax ER when a strong inducer of both CYP3A4 and P-gp (e.g., carbamazepine) is co-administered. Conversely, on discontinuation of the strong inducer, it may be necessary to decrease the dose of Palimax ER.
- Co-administration of divalproex sodium increased Cmax and AUC of Palimax ER by approximately 50%. Adjust dose of Palimax ER if necessary based on clinical assessment.
Side Effects
The most common adverse reactions of Palimax ER are tachycardia, akathisia, somnolence, tremor, dystonia, cogwheel rigidity, anxiety, weight increased, dyspepsia, constipation, nasopharyngitis etc.
Pregnancy & Lactation
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Paliperidone should be used during pregnancy only if the potential benefits justifies the potential risk to the fetus. Paliperidone is excreted in human breast milk. The known benefits of breastfeeding should be weighed against the unknown risks of infant exposure to Paliperidone.
Precautions & Warnings
Caution should be exercised when Palimax ER is prescribed in patients with known Cardiovascular diseases, QT prolongation, Neuroleptic malignant syndrome, Tardive dyskinesia, Hyperglycemia, Dyslipidemia, Obesity, Hyperprolactinemia, Leukopenia, Neutropenia, Agranulocytosis, Seizures, Potential for Cognitive & Motor impairment etc.
Use in Special Populations
Pediatric use: Safety and effectiveness in the treatment of schizophrenia not established in patients less than 12 years of age. Safety and effectiveness in the treatment of schizoaffective disorder not established in patients less than 18 years of age.
Overdose Effects
Overdose of Palimax ER is limited; there is no specific antidote to Palimax ER. If overdose occurs general supportive and symptomatic measures should be employed.
Therapeutic Class
Atypical neuroleptic drugs
Storage Conditions
Store in a cool and dry place, away from light. Keep out of reach of children.
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