Glustin Max 750 mg+50 mg Tablet (1 Strip=10 Pieces)
Original price was: 120.00৳ .114.00৳ Current price is: 114.00৳ .
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Bone and Joint injuries
Pharmacology
In humans, about 90 percent of glucosamine, administered as an oral dose of glucosamine sulfate, is absorbed from the digestive tract. Predominantly metabolized by liver & excreted through urine.
Diacerein: This is used for the treatment of Osteoarthritis. It has also analgesic, antipyretic and anti-inflammatory activity. It release in vitro and directly inhibits InterLeukin-1(IL-1) synthesis, which is the main cytokine involved in cartilage destruction. Due to specific mode of action, it have been shown to have disease-modifying effect in experimental models of osteoarthritis and in human subjects with finger joint and knee osteoarthritis.
Oral bioavailability of Diacerein 56%. Concurrent intake of food delays the time to peak concentration but associated with a 25% increase in absorption. Therefore, diacerein is best given with food. Mainly binds with protein albumin. Diacerein is metabolized extensively (100%) in liver following oral dosing. Urinary excretion of diacerein in the form of its metabolites has ranged between 35% and 60%.
Dosage & Administration
Use in children and adolescents: The safety and effectiveness of children and adolescents under the age of 18 years have not been established.
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